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Since levodopa competes with certain amino acids for transport across the gut wall.the absorption of levodopa may be impaired in some patients on a high protein diet.

Infrequently.patients may develop a drop in white blood cell count during carbidopa-levodopa therapy. This is a significant reason to temporarily.if not permanently.stop treatment.

The management of NMS should include. 1) intensive symptomatic treatment and medical monitoring and 2) treatment of any concomitant serious medical problems for which specific treatments are available. Dopamine agonists.such as bromocriptine.and muscle relaxants.such as dantrolene.are often used in the treatment of NMS. however.their effectiveness has not been demonstrated in controlled studies.

NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia. Neurological findings.including muscle rigidity.involuntary movements.order sinemet drug consciousness.mental status changes. other disturbances.such as autonomic dysfunction.tachycardia.tachypnea.sweating.hyper- or hypotension. laboratory findings.such as creatine phosphokinase elevation.leukocytosis.myoglobinuria.and increased serum myoglobin have been reported.

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