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Fatal overdoses.both accidental and intentional.have been reported in adults and children who have ingested colchicine [See OVERDOSE ]. Colchicine capsules should be kept out of the reach of children.

Prophylaxis of gout attack during initiation of therapy with allopurinol and uricosuric drugs.

If co-administration of colchicine capsules and a CYP3A4 inhibitor is necessary.the dose of colchicine capsules should be adjusted by either reducing the daily dose or reducing the dose frequency.and the patient should be monitored carefully for colchicine toxicity [See CLINICAL PHARMACOLOGY ].

To treat a gout attack.for best results take colchicine at the first sign of the attack. The longer you wait to start taking the medication.the less effective it may be.

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