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a history of heart attack.stroke.or blood clot. heart disease.congestive heart failure.high blood pressure. liver or kidney disease. asthma. polyps in your nose. or if you smoke.

Mefenamic acid may also cause stomach or intestinal bleeding.which can be fatal. These conditions can occur without warning while you are using mefenamic acid.especially in older adults.

Inform patients not to use low-dose aspirin concomitantly with Price of ceftin in india Ponstel until they talk to their healthcare provider (see PRECAUTIONS. Drug Interactions).

PONSTEL (mefenamic acid) should not be given to patients who have experienced asthma.urticaria.or allergic-type reactions after taking aspirin or other NSAIDs. Severe.rarely fatal.anaphylactic-like reactions to NSAIDs have been reported in such patients (see WARNINGS – Anaphylactoid Reactions.and PRECAUTIONS – Preexisting Asthma ).

You should not take Ponstel if you already have stomach bleeding or an active ulcer.or a bowel disorder such as ulcerative colitis.or if you have kidney disease.

Use the lowest effective dosage for the shortest possible duration. Avoid administration of more than one NSAID at a time. Avoid use in patients at higher risk unless benefits are expected to order ponstel side the increased risk of bleeding. For such patients.as well as those with active GI bleeding.consider alternate therapies other than NSAIDs. Remain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapy. If order ponstel side serious GI adverse event is suspected.promptly initiate evaluation and treatment.and discontinue PONSTEL until a serious GI adverse event is ruled out. In the setting of concomitant use of low-dose aspirin for cardiac prophylaxis.monitor patients more closely for evidence of GI bleeding (see PRECAUTIONS. Drug Interactions ).

Mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro. Mefenamic acid concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because mefenamic acid is an inhibitor of prostaglandin synthesis.its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

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